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Jul 31

Jul 31 Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

Kratom is widely consumed in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid receptor agonist.

May 29

May 29 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

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Synopsis

Mitragynine is the major active alkaloid of Mitragyna speciosa (kratom). In mice, this compound is converted to an active metabolite, 7-hydroxymitragynine, which mediates its analgesic effect via the mu-opioid receptor.

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Jul 31 Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy

May 29 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

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